MS – Multiple Sclerosis
Multiple Sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system. Although the pathogenesis of MS remains to be elucidated, an autoimmune response against myelin antigens is thought to contribute to the immunopathological mechanisms of the disease.
In previous studies N-glucosylation has been characterized as one of the possible post-translational modification involved in MS pathogenesis that triggers an autoantibody response. The researchers of the Laboratory of Peptide and Protein Chemistry and Biology (PeptLab), promoters of Toscana Biomarkers, used glucosylated peptides to detect biomarkers in a significant number of MS patients. These results guided Toscana Biomarkers to the development of a diagnostic immunoassay for MS in cooperation with PeptLab.
